How long does it take for pneumonia shot to work Tue, Feb 23, 10 02:02PM by roman Generally for flu shots, it is around a couple of weeks. The same time frame holds good for pneumonia shots too. Taking it once would suffice for life in healthy individuals TAGS: 1. pneumonia shot cdc 2. medicare pneumonia shot 3. pneumonia shot effectiveness 4. pneumonia shot mayo 5. pneumonia shot pain