One can take the pneumonia shot twice, especially if has damaged or has no spleen, suffering from sickle cell disease, HIV, AIDS, cancer, leukemia, lymphoma, multiple myeloma, kidney failure, nephrotic syndrome, an organ or bone marrow transplant, or is taking medication which has decreased their immunity, like chemotherapy or long-term steroids. Pneumonia shot is injected into the body to stimulate the normal immune system so as to produce antibodies which are directed against pneumococcus bacteria. It offers protection against pneumonia.